Histone demethylases inhibitor GSK J1, Purity ≥98%

Synonym: 1373422-53-7; GSK-J1; GSK J1; GSKJ1; 3-[[2-Pyridin-2-Yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-Yl)pyrimidin-4-Yl]amino]propanoic acid; Histone demethylases inhibitor

CAS Number: 1373422-53-7
Compound CID: 56963315

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK J1, soluble in DMSO and insoluble in ethanol and water, prevents the removal of methyl groups from histones, influencing gene expression by maintaining histone methylation. It targets JMJD3 (KDM6B) and UTX (KDM6A).

Molecular Weight

389.45

Molecular Formula

C₂₂H₂₃N₅O₂

Targets

JMJD3 (KDM6B): 28 nM; UTX (KDM6A): 53 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 70 mg/mL (179.74 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK J1 is a selective Jumonji demethylase inhibitor used to study the impact of histone demethylation on gene expression.