Properties
Description
GSK467, soluble in DMSO, water and ethanol, prevents the removal of methyl groups from histones, influencing gene expression by maintaining histone methylation. It targets KDM5 and KDM5.
Molecular Formula
C17H13N5O2
Targets
KDM5: 10 nM (Ki); KDM5: 26 nM
Solubility
DMSO: 7 mg/mL (21.92 mM); Water: <1 mg/mL; Ethanol: <1 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
GSK467 is an inhibitor of LSD1 used to study epigenetic regulation in various diseases.
