Histone demethylases inhibitor IOX1, Purity ≥98%

Synonym: 5852-78-8; IOX 1; Iox-1; Histone demethylases inhibitor

CAS Number: 5852-78-8
Compound CID: 459617

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

IOX1, soluble in DMSO and insoluble in ethanol and water, prevents the removal of methyl groups from histones, influencing gene expression by maintaining histone methylation. It targets KDM4C, KDM6B, KDM2A, KDM3A, KDM4E, KDM4E, and PHD2.

Molecular Weight

189.17

Molecular Formula

C₁₀H₇NO₃

Targets

KDM4C: 0.6 μM; KDM6B: 1.6 μM; KDM2A: 1.8 μM; KDM3A: 0.1 μM; KDM4E: 2.3 μM; KDM4E: 19 μM; PHD2: 33 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 36 mg/mL (190.3 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

IOX1 can inhibit multiple Jumonji histone demethylases, helping in studies on histone modification and gene regulation.