Properties
Description
IOX1, soluble in DMSO and insoluble in ethanol and water, prevents the removal of methyl groups from histones, influencing gene expression by maintaining histone methylation. It targets KDM4C, KDM6B, KDM2A, KDM3A, KDM4E, KDM4E, and PHD2.
Molecular Formula
C10H7NO3
Targets
KDM4C: 0.6 μM; KDM6B: 1.6 μM; KDM2A: 1.8 μM; KDM3A: 0.1 μM; KDM4E: 2.3 μM; KDM4E: 19 μM; PHD2: 33 μM
Solubility
DMSO: 36 mg/mL (190.3 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
IOX1 can inhibit multiple Jumonji histone demethylases, helping in studies on histone modification and gene regulation.
