HMT inhibitor 3-Deazaneplanocin A HCl, Purity ≥98%

Synonym: 120964-45-6; DZNep; NSC 617989; DZNep HCl; Histone methyltransferase inhibitor

CAS Number: 120964-45-6
Compound CID: 14563109

Product Size

2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

3-Deazaneplanocin A HCl, soluble in DMSO and water and insoluble in ethanol, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets S-adenosylhomocysteine hydrolase.

Molecular Weight

298.73

Molecular Formula

C₁₂H₁₅ClN₄O₃

Targets

S-adenosylhomocysteine hydrolase (): 50 pM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 49 mg/mL (164.03 mM); Water: 49 mg/mL (164.03 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

3-Deazaneplanocin A HCl is used to study the inhibition of histone methyltransferases like EZH2 in epigenetic regulation.