HMT inhibitor Chaetocin, Purity ≥98%

Synonym: 28097-03-2; Chaetocin; Chaetocin a; (+)-Chaetocin; CHEMBL1089316; Histone methyltransferase inhibitor

CAS Number: 28097-03-2
Compound CID: 11657687

Product Size

1 mg; 2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Chaetocin, soluble in warmed DMSO and insoluble in water and ethanol, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets dSU(VAR)3-9, mouse G9a, and Neurospora crassa DIM5.

Molecular Weight

696.84

Molecular Formula

C₃₀H₂₈N₆O₆S₄

Targets

dSU(VAR)3-9: 0.8 μM; mouse G9a: 2.5 μM; Neurospora crassa DIM5: 3 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 87 mg/mL (124.85 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Chaetocin can be used to inhibit histone methyltransferase SUV39H1, affecting heterochromatin formation.