HMT inhibitor CM-272, Purity ≥98%

Synonym: 1846570-31-7; CM272; CM 272; Histone methyltransferase inhibitor

CAS Number: 1846570-31-7
Compound CID: 118607432

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CM-272, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DNMT1, DNMT3A, DNMT3B, and G9a.

Molecular Weight

478.63

Molecular Formula

C₂₈H₃₈N₄O₃

Targets

DNMT1: 382 nM; DNMT3A: 85 nM; DNMT3B: 1200 nM; G9a: 8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 95 mg/mL (198.48 mM); Water: Insoluble; Ethanol: 95 mg/mL (198.48 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

CM-272 can be used to inhibit both G9a and DNMT1, impacting both histone and DNA methylation.

Storage

Store at -20ºC.