Properties
Description
CM-579 inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DNA methyltransferase, DNMT1, DNMT3A, DNMT3B, and G9a.
Molecular Formula
C29H40N4O3
Targets
DNA methyltransferase: 32 nM; DNMT1: 1.5 nM; DNMT3A: 92 nM; DNMT3B: 1000 nM; G9a: 16 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CM-579 can be used as an inhibitor of both G9a and DNMT1 for studying epigenetic modifications.