Properties
Description
CPI-169, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH1, EZH2 WT, and EZH2 Y641N.
Molecular Formula
C27H36N4O5S
Targets
EZH1: 6.1 nM; EZH2 WT: 0.24 nM; EZH2 Y641N: 0.51 nM
Solubility
DMSO: 88 mg/mL (166.45 mM); Water: Insoluble; Ethanol: 88 mg/mL (166.45 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CPI-169 can be used to inhibit EZH2, thereby affecting gene silencing and potential cancer pathways.