HMT inhibitor CPI-169, Purity ≥98%

Synonym: 1450655-76-1; CPI 169; CPI169; Histone methyltransferase inhibitor

CAS Number: 1450655-76-1
Compound CID: 78357814

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CPI-169, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH1, EZH2 WT, and EZH2 Y641N.

Molecular Weight

528.66

Molecular Formula

C₂₇H₃₆N₄O₅S

Targets

EZH1: 6.1 nM; EZH2 WT: 0.24 nM; EZH2 Y641N: 0.51 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (166.45 mM); Water: Insoluble; Ethanol: 88 mg/mL (166.45 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

CPI-169 can be used to inhibit EZH2, thereby affecting gene silencing and potential cancer pathways.