Properties
Description
EI1, soluble in warmed DMSO and insoluble in water and ethanol, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH2 WT and EZH2 Y641F mutant type.
Molecular Formula
C23H26N4O2
Targets
EZH2 WT: 15 nM (EC50); EZH2 Y641F mutant type: 13 nM
Solubility
Warmed DMSO: 39 mg/mL (99.87 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
EI1 can be used to inhibit EZH2, affecting H3K27 methylation and potentially reversing gene silencing.
