HMT inhibitor EPZ-5676, Purity ≥98%

Synonym: 1380288-87-8; EPZ5676; EPZ 5676; Pinometostat; Histone methyltransferase inhibitor

CAS Number: 1380288-87-8
Compound CID: 57345410

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

EPZ-5676, soluble in warmed DMSO and warmed ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DOT1L.

Molecular Weight

562.7

Molecular Formula

C₃₀H₄₂N₈O₃

Targets

DOT1L: 80 pM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 88 mg/mL (156.38 mM); Water: Insoluble; Warmed ethanol: 81 mg/mL (143.94 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

EPZ-5676 can be used to inhibit DOT1L, specifically blocking H3K79 methylation and affecting leukemia cells.