Properties
Description
EPZ-5676, soluble in warmed DMSO and warmed ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DOT1L.
Molecular Formula
C30H42N8O3
Targets
DOT1L: 80 pM (Ki)
Solubility
Warmed DMSO: 88 mg/mL (156.38 mM); Water: Insoluble; Warmed ethanol: 81 mg/mL (143.94 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
EPZ-5676 can be used to inhibit DOT1L, specifically blocking H3K79 methylation and affecting leukemia cells.