HMT inhibitor EPZ-6438, Purity ≥98%

Synonym: 1403254-99-8; EPZ6438; EPZ 6438; Tazemetostat; Histone methyltransferase inhibitor

CAS Number: 1403254-99-8

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

EPZ-6438, soluble in warmed DMSO and insoluble in water and ethanol, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH2.

Molecular Weight

572.74

Molecular Formula

C₃₄H₄₄N₄O₄

Targets

EZH2: 2.5 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 4 mg/mL (6.98 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

EPZ-6438 (Tazemetostat) can be used to inhibit EZH2, impacting histone methylation in cancer therapy.