HMT inhibitor EPZ004777, Purity ≥98%

Synonym: 1338466-77-5; EPZ 004777; EPZ-004777; Histone methyltransferase inhibitor

CAS Number: 1338466-77-5

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

EPZ004777, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DOT1L.

Molecular Weight

539.67

Molecular Formula

C₂₈H₄₁N₇O₄

Targets

DOT1L: 0.4 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 95 mg/mL (176.03 mM); Water: Insoluble; Ethanol: 95 mg/mL (176.03 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

EPZ004777 can be used to inhibit DOT1L, impacting histone methylation and leukemogenesis.