HMT inhibitor EPZ005687, Purity ≥98%

Synonym: 1396772-26-1; EPZ-005687; Histone methyltransferase inhibitor

CAS Number: 1396772-26-1
Compound CID: 60160561

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

EPZ005687, soluble in DMSO and insoluble in ethanol and water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH2.

Molecular Weight

539.67

Molecular Formula

C₃₂H₃₇N₅O₃

Targets

EZH2: 24 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 2 mg/mL (3.7 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

EPZ005687 can be used to inhibit EZH2, affecting H3K27 methylation and gene expression modulation.