Properties
Description
GSK126, soluble in warmed DMSO and insoluble in water and ethanol, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH2.
Molecular Formula
C31H38N6O2
Solubility
Warmed DMSO: 3 mg/mL (5.69 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
GSK126 can be used to inhibit EZH2, resulting in modulation of histone H3K27 methylation.
