Properties
Description
GSK343, soluble in warmed DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH1 and EZH2.
Molecular Formula
C31H39N7O2
Targets
EZH1: 240 nM; EZH2: 4 nM
Solubility
Warmed DMSO: 1 mg/mL (1.84 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.54 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
GSK343 can be used to inhibit EZH2 and study its effects on histone modification and cancer pathways.
