HMT inhibitor GSK503, Purity ≥98%

Synonym: 1346572-63-1; GSK-503; GSK 503; Histone methyltransferase inhibitor

CAS Number: 1346572-63-1
Compound CID: 67469117

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK503, soluble in DMSO and warmed ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH2.

Molecular Weight

526.67

Molecular Formula

C₃₁H₃₈N₆O₂

Targets

EZH2: 8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (161.39 mM); Water: Insoluble; Warmed ethanol: 22 mg/mL (41.77 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK503 can be used to inhibit EZH2, impacting histone methylation and gene silencing mechanisms.