HMT inhibitor MI-2, Purity ≥98%

Synonym: 1271738-62-5; Menin-MLL inhibitor 2; Histone methyltransferase inhibitor

CAS Number: 1271738-62-5
Compound CID: 54765302

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MI-2, soluble in warmed DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets Menin-MLL and Menin-MLL.

Molecular Weight

375.55

Molecular Formula

C₁₈H₂₅N₅S₂

Targets

Menin-MLL; Menin-MLL: 446 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 71 mg/mL (189.05 mM); Water: Insoluble; Ethanol: 71 mg/mL (189.05 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

MI-2 can be used to inhibit Menin-MLL interaction, affecting leukemogenesis driven by MLL fusion proteins.

Storage

Store at -20ºC.