HMT inhibitor PF-06726304, Purity ≥98%

Synonym: 1616287-82-1; PF 06726304; PF06726304; Histone methyltransferase inhibitor

CAS Number: 1616287-82-1
Compound CID: 86723730

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF-06726304, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH2 WT and EZH2 Y641N.

Molecular Weight

446.32

Molecular Formula

C₂₂H₂₁Cl₂N₃O₃

Targets

EZH2 WT: 0.7 nM (Ki); EZH2 Y641N: 3 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 9 mg/mL (20.16 mM); Water: Insoluble; Ethanol: 20 mg/mL (44.81 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF-06726304 can be used to inhibit CDK9 in cancer research, affecting transcription regulation.