Properties
Description
SGC 0946, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DOT1L.
Molecular Formula
C28H40BrN7O4
Solubility
DMSO: 98 mg/mL (158.43 mM); Water: Insoluble; Ethanol: 98 mg/mL (158.43 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
SGC 0946 can be used to inhibit the DOT1L histone methyltransferase, which is critical in leukemic pathogenesis.
