HMT inhibitor UNC 0224, Purity ≥98%

Synonym: 1197196-48-7; UNC 0224; UNC-0224; Histone methyltransferase inhibitor

CAS Number: 1197196-48-7
Compound CID: 44251522

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

UNC 0224 inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EHMT1/GLP/KMT1D, G9a, G9a, and G9a.

Molecular Weight

485.67

Molecular Formula

C₂₆H₄₃N₇O₂

Targets

EHMT1/GLP/KMT1D: 20-58 nM; G9a: 15 nM; G9a: 2.6 nM (Ki); G9a: 23 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

UNC 0224 can be used to inhibit G9a/GLP methyltransferase activity, studying its role in transcriptional repression.