HMT inhibitor UNC-1999, Purity ≥98%

Synonym: 1431612-23-5; UNC 1999; UNC1999; Histone methyltransferase inhibitor

CAS Number: 1431612-23-5
Compound CID: 72551585

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

UNC-1999, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH1 and EZH2.

Molecular Weight

569.74

Molecular Formula

C₃₃H₄₃N₇O₂

Targets

EZH1: 45 nM; EZH2: 2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 17 mg/mL (29.84 mM); Water: Insoluble; Ethanol: 43 mg/mL (75.47 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

UNC-1999 can be used to inhibit EZH2/1, probing their role in trimethylating H3K27 and its relevance in cancer.

Storage

Store at -20ºC.