Properties
Description
UNC-1999, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH1 and EZH2.
Molecular Formula
C33H43N7O2
Targets
EZH1: 45 nM; EZH2: 2 nM
Solubility
DMSO: 17 mg/mL (29.84 mM); Water: Insoluble; Ethanol: 43 mg/mL (75.47 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
UNC-1999 can be used to inhibit EZH2/1, probing their role in trimethylating H3K27 and its relevance in cancer.
