Properties
Description
UNC0321 inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EHMT1/GLP/KMT1D, G9a, and G9a.
Molecular Formula
C27H45N7O3
Targets
EHMT1/GLP/KMT1D: 15-23 nM; G9a: 63 pM (Ki); G9a: 6-9 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
UNC0321 can be used to examine the effects of G9a/GLP inhibition on chromatin and gene expression.