Properties
Description
UNC0646, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets G9a and GLP.
Molecular Formula
C36H59N7O2
Targets
G9a: 6 nM; GLP: <15 nM
Solubility
DMSO: 31 mg/mL (49.84 mM); Water: Insoluble; Ethanol: 47 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
UNC0646 can be used to study the biochemical and cellular roles of G9a inhibition in histone methylation.
