HMT inhibitor YF-2, Purity ≥98%

Synonym: 1311423-89-8; YF2; YF 2; Histone methyltransferase inhibitor

CAS Number: 1311423-89-8
Compound CID: 53230697

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

YF-2, soluble in DMSO, water and ethanol, inhibits enzymes that add acetyl groups to histones, affecting chromatin structure and regulating gene transcription. It targets CBP, GCN5, and GCN5/PCAF.

Molecular Weight

430.85

Molecular Formula

C₂₀H₂₂ClF₃N₂O₃

Targets

CBP: 2.75 μM (EC₅₀); GCN5: 49.31 μM (EC₅₀); GCN5/PCAF: 29.04 μM (EC₅₀)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 78 mg/mL (181.03 mM); Water: 78 mg/mL (181.03 mM); Ethanol: 78 mg/mL (181.03 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

YF-2 can be used to inhibit histone acetyltransferases p300/CBP, aiding in cancer research.