Cat. No.: X24-09-YM062
HSP inhibitor, 17-DMAG HCl, Purity ≥98%
Synonym: 467214-21-7; 17DMAG; NSC 707545; [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(Dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate; hydrochloride; HSP inhibitor
- MDL: MFCD09026908
- CAS Number: 467214-21-7
- Compound CID: 9852573
Product Size
25 mg; 50 mg; 100 mg; 200 mg
Properties
Description
17-DMAG HCl, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting HSP. The molecular weight of the compound is 653.2, and its molecular formula is C32H48N4O8·HCl. It targets the HSP90 (Cell-free assay).
Molecular Formula
C32H48N4O8·HCl
Targets
HSP90 (Cell-free assay)
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 127 mg/mL (194.42 mM); Water: insoluble; Ethanol: insoluble; In vivo: 1% DMSO + 30% polyethylene glycol + 1% Tween 80, 28 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
17-DMAG HCl can be studied extensively for its potential therapeutic applications in the treatment of various cancers by destabilizing and degrading oncogenic client proteins, leading to the inhibition of tumor growth and progression.
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