The Significance of High-Throughput Screening of Glucose

Glucose is acknowledged as a vital hydrocarbon and the main energy resource available to all living lives. In the organism, glucose is taken up and absorbed by cells through the action of insulin. Then it provides the energy required for body movement and many biological activities. High-throughput screening (HTS) of glucose is usually performed utilizing chemical or biological screening methods. Among these, chemical screens usually involve combining glucose with compounds library in a binding screen to find specific binding compounds to glucose. Scientists typically design libraries of compounds based on the chemical structure and bioactive characteristics of glucose. These compound libraries may contain thousands of samples, each of which needs to be tested to determine its similarity to glucose. These data can be used to screen potential drug and industrial candidates and to optimize their design. Biological screens usually utilize cellular, enzymatic, or other biomolecules that bind specifically to glucose for HTS of glucose.

Fig.1 Structure of glucose. (Wikipedia)

HTS of Glucose at CD BioGlyco

Glucose is considered a vital part of normal organism metabolism which represents a vital resource of energy for biological life. CD BioGlyco provides clients with HTS services using the most professional Strategies for HTS that allow for rapid and accurate screening of large numbers of samples. Recently, several new HTS techniques have emerged that have the potential for efficient HTS of glucose ligands. We provide glucose HTS service with state-of-the-art technical equipment. Our services include but are not limited to:

• HTS of glucose using Mass Spectrometry
  Different mass spectra are selected for analysis depending on the sample, such as Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TO-MS), and Liquid chromatography-mass spectrometry (LC-MS), etc. These techniques allow rapid analysis for multiple samples to screen glucose in a high throughput approach.
• HTS of glucose using Capillary Electrophoresis-Mass Spectrometry (CE-MS)
  We combine two techniques, capillary electrophoresis separation and mass spectrometry detection. The components can be separated and determined simultaneously, and the structure and properties of the compounds can be accurately analyzed and identified.

Fig.2 The analysis process of CE-MS. (CD BioGlyco)

Applications

• Searching for new drug inhibitors
• Glycated hemoglobin testing
• In-depth understanding of the mechanisms regulating energy metabolism

Advantages of Us

• Widely applicable to various compounds and molecules
• Non-destructive analysis
• Standardized and customized services

CD BioGlyco has a comprehensive and versatile glycobiology laboratory and experienced researchers. We provide accurate, high-quality, and data-driven glucose HTS services to our clients. If you are interested in our services, please contact us for more details. We are looking forward to helping you with your research.