Human Milk Oligosaccharides (HMOs)
Human milk oligosaccharides (HMO) are a class of complex carbohydrates naturally present in breast milk. More than 200 HMO molecules with different structures have been identified so far. It is usually composed of glucose (Glc), galactose (Gal), sialic acid (Neu5Ac), fucose (Fuc), and N-acetylglucosamine (GlcNAc) in different arrangements and combinations. HMO not only contributes to the development of the immune system, but is also associated with cognitive development, intestinal barrier function, and the regulation of inflammatory responses. CD BioGlyco provides clients with a wide range of HMO products that undergo strict quality control to ensure their purity and biological activity, supporting the rigor and innovative exploration of scientific research.
Fig.1 The beneficial effects of HMOs in supporting digestive health, immunity, and cognition. (Hill, et al., 2021)
According to the chemical structure, HMOs are divided into fucosylated neutral HMO (35-50%), non-fucosylated neutral HMO (42-55%), and sialylated HMO (12-14%). We provide clients with these three types of HMO products to meet diverse research and application needs. Each product has unique properties and functions, plays an important role in scientific research, and provides strong support for fields such as nutritional science, intestinal health, and immune research.
Fucosylated neutral HMOs are a class of oligosaccharides commonly found in breast milk, such as molecules such as 2'-fucosyllactose and 3-fucosyllactose. Their structural characteristics are that one or more fucose groups are attached to their core structure. Studies have shown that these HMOs play an important role in supporting the immune system and intestinal development of newborns. They help prevent infection by competitively binding with pathogens and preventing them from attaching to intestinal epithelial cells. We provide clients with a variety of high-quality fucosylated neutral HMO products, only some of which are listed here. Please find more product information in the drop-down list.
Non-fucosylated neutral HMOs are neutral oligosaccharides that do not contain fucose and have the function of supporting the growth of probiotics and maintaining the balance of intestinal microecology. By promoting the proliferation of beneficial bacteria such as bifidobacteria, HMO helps to establish a healthy intestinal microenvironment, which is conducive to the digestive health and immune system maturation of infants. Some non-fucosylated neutral HMO products are listed below. Please find more product information in the drop-down list. These products are used to study the effects of HMO on the intestinal microbiome, its potential in regulating and enhancing the immune system, etc.
Sialylated HMO is a member of the HMO family, characterized by sialic acid attached to the end of the sugar chain. This type of HMO is not only an important nutrient for brain development but also has significant antiviral and antibacterial properties. Sialylated HMO supports the development of the infant's nervous system, especially the structural and functional development of the brain. We provide clients with high-quality sialylated HMO products that undergo strict quality control to ensure purity and potency. We are committed to meeting clients' needs with excellent products and services to promote your scientific innovation. Some sialylated HMO products are listed below. Please find more product information in the drop-down list.
DOI: 10.3390/nu16091287
Journal: Nutrients
IF: 4.8
Published: 2024
Results: The authors investigated the association of different levels and patterns of HMO in breast milk with the composition of the infant gut microbiota. The results showed that the HMO pattern in mature breast milk was associated with certain gut microbiota in breastfed infants. For example, high levels of 3-fucosyllactose, lacto-N-fucopentaose III, and lacto-N-neodifucohexaose II were positively correlated with the relative abundance of Bifidobacterium breve. High levels of monofucosyllacto-N-hexaose-III and monofucosyllacto-N-neohexaose were positively correlated with Bifidobacterium dentium and Bifidobacterium bifidum. Lacto-N-neotetraose, 6′-sialyllactose, and sialyllacto-N-tetraose-b were negatively correlated with Bifidobacterium breve.
At CD BioGlyco, our HMO products are designed for research and innovation, with high purity and reliable quality to support many research fields. We also provide custom synthesis services for HMOs and their derivatives to support your unique projects and goals. Please feel free to contact us.
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