Hydroxylase inhibitor, Nepicastat HCl, Purity ≥98%

Synonym: 170151-24-3; RS-25560-197; SYN117; 4-(Aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione; hydrochloride; Hydroxylase inhibitor

MDL: MFCD00954638
CAS Number: 170151-24-3
Compound CID: 9840545

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nepicastat HCl, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting hydroxylases. The molecular weight of the compound is 331.81, and its molecular formula is C₁₄H₁₅F₂N₃S·HCl. It targets the Bovine dopamine-beta-hydroxylase and Human dopamine-beta-hydroxylase.

Molecular Weight

331.81

Molecular Formula

C₁₄H₁₅F₂N₃S·HCl

Targets

Bovine dopamine-beta-hydroxylase

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 59 mg/mL (177.8 mM); Water: insoluble; Ethanol: insoluble; In vivo: 1% CMC Na, 19 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Nepicastat HCl can be studied extensively for its potential therapeutic applications in the treatment of hypertension by modulating sympathetic nervous system activity.