Discovering the Essence of Hypromellose through Advanced Analysis

Hypromellose is one of the non-ionic cellulose blend ethers. Hypromellose is often used as a lubricant in ophthalmology or as an excipient in orally consumed drugs. At CD BioGlyco, we provide professional hypromellose analysis services to clients worldwide.

• Properties
  Hypromellose is a white or off-white fibrous or granular powder. It is practically insoluble in anhydrous ethanol, ether, and acetone, and dissolves in cold water to give a clear or slightly turbid colloidal solution.
• Identification
  • The sample is made into a slurry liquid with hot water and cooled. Then an appropriate amount of sulphuric acid solution of anthrone is added to it. If a blue-green layer appears at the junction of the liquid, the sample is hypromellose.
  • The addition of boiling water to hypromellose results in the formation of an insoluble slurry and hypromellose can be identified based on this characteristic.
• Viscosity
  Hot water is added to the hypromellose and stirred thoroughly, followed by cooling in an ice water bath. After cooling, the viscosity is determined using a viscometer.
• Acidity and alkalinity
  We determine the pH of hypromellose by using an acidimeter. The pH of hypromellose should be 5.0 to 8.0.
• Insoluble matter in water
  After adding hot water to hypromellose, cooling, and filtering, the amount of insoluble matter in water is determined.
• Loss on drying
  Place the hypromellose in a high-temperature environment for drying. The weight loss of dried hypromellose should not exceed 5.0%.
• Scorch residue
  Hypromellose is taken and fully cauterized, leaving a residue of not more than 1.5% after completion.
• Content determination
  Depending on the methoxy and hydroxypropoxy content, hypromellose can be classified into different types. Therefore, we also offer the analysis of methoxy and hydroxypropoxy content in hypromellose.
  Gas chromatography: The gas chromatogram of hypromellose is determined using phenyl-methylpolyoxysilane as the stationary phase. The content of methoxy and hydroxypropoxy in hypromellose can be calculated from the peak area of the chromatogram.

Frequently Asked Question

• As a pharmaceutical excipient, how does hypromellose perform its function?
  Hypromellose releases pharmaceuticals in a controlled manner, effectively prolonging the duration of pharmaceutical release and thus its therapeutic effect. Hypromellose, when used in matrix tablets, creates a viscous gel barrier in and around the tablets.
• What is Hypromellose used for?
  Construction industry: It can be used as a water-retaining agent and retarder for cement mortar to make the mortar pumpable.
  Ceramic manufacturing industry: It is widely used as a binder in the manufacture of ceramic products.
  Coating industry: It is used as a thickener, dispersant, and stabilizer in the coating industry, and has good compatibility in water or organic solvents.
  Pharmaceutical industry: It can be used as a coating material, speed-control polymer material for slow-release preparation, stabilizer, and tablet binder.

Advantages

• We combine multidisciplinary knowledge and technologies to provide a wide range of Pharmaceutical Excipient Analysis Services to our clients.
• We perform hypromellose analysis accurately and rapidly by using advanced analysis techniques, such as high performance liquid chromatography (HPLC) and mass spectrometry (MS).
• We have an efficient workflow and service mechanism that allows us to respond quickly to client needs and provide timely results of hypromellose analyses.

CD BioGlyco has extensive expertise in the field of Pharmaceutical and Biological Analysis. Our service team is equipped with state-of-the-art technology to meet your requirements, whether it is the analysis of the physicochemical properties of hypromellose or the evaluation of its biological activity. Please feel free to contact us if you have any questions or are interested in our hypromellose analysis services.