IAP antagonist Birinapant, Purity ≥98%

Synonym: 1260251-31-7; Birinapant; Birinapant (TL32711); TL 32711; (2S)-N-[(2S)-1-[(2R,4S)-2-[[6-Fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2-(methylamino)propanamide; IAP antagonist

MDL: MFCD25976869
CAS Number: 1260251-31-7
Compound CID: 49836020

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Birinapant, soluble in DMSO and ethanol and insoluble in water, is a molecule designed to neutralize the function of IAPs, thereby promoting apoptosis, especially in cancer cells. It targets cIAP1 and XIAP.

Molecular Weight

806.94

Molecular Formula

C₄₂H₅₆F₂N₈O₆

Targets

cIAP1: <1 nM (Kd); XIAP: 45 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (107.81 mM); Water: Insoluble; Ethanol: 48 mg/mL (59.48 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Birinapant can be used to explore its double inhibitor function against IAP proteins, promoting apoptosis and enhancing cancer therapy.