IAP antagonist Birinapant, Purity ≥98%

Synonym: 1260251-31-7; Birinapant; Birinapant (TL32711); TL 32711; (2S)-N-[(2S)-1-[(2R,4S)-2-[[6-Fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2-(methylamino)propanamide; IAP antagonist

MDL: MFCD25976869
CAS Number: 1260251-31-7
Compound CID: 49836020

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Birinapant, soluble in DMSO and ethanol and insoluble in water, is a molecule designed to neutralize the function of IAPs, thereby promoting apoptosis, especially in cancer cells. It targets cIAP1 and XIAP.

Molecular Weight

806.94

Molecular Formula

C₄₂H₅₆F₂N₈O₆

Targets

cIAP1: <1 nM (Kd); XIAP: 45 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (107.81 mM); Water: Insoluble; Ethanol: 48 mg/mL (59.48 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Birinapant can be used to explore its double inhibitor function against IAP proteins, promoting apoptosis and enhancing cancer therapy.

Storage

Store at -20ºC.