IAP antagonist GDC-0152, Purity ≥98%

Synonym: 873652-48-3; GDC-0152; GDC-0152 free base; UNII-4KW1M48SHS; GDC 0152; 4KW1M48SHS; (S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide; IAP antagonist

CAS Number: 873652-48-3
Compound CID: 46940575

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GDC-0152, soluble in DMSO, water and ethanol, is a molecule designed to neutralize the function of IAPs, thereby promoting apoptosis, especially in cancer cells. It targets cIAP1-BIR2, cIAP1-BIR3, cIAP2-BIR2, cIAP2-BIR3, MLXBIR3SG, XIAP-BIR2, and XIAP-BIR3.

Molecular Weight

498.64

Molecular Formula

C₂₅H₃₄N₆O₃S

Targets

cIAP1-BIR2: 14.5 μM (Ki); cIAP1-BIR3: 17 nM (Ki); cIAP2-BIR2: 9.6 μM (Ki); cIAP2-BIR3: 43 nM (Ki); MLXBIR3SG: 14 nM (Ki); XIAP-BIR2: 112 nM (Ki); XIAP-BIR3: 28 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 98 mg/mL (196.53 mM); Water: 3 mg/mL (6.01 mM); Ethanol: 98 mg/mL (196.53 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

GDC-0152 can be studied for its role in binding to IAPs and promoting apoptotic pathways in cancer treatment.