IAP antagonist LCL-161, Purity ≥98%

Synonym: 1005342-46-0; LCL161; LCL-161; (S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide; IAP antagonist

MDL: MFCD23160049
CAS Number: 1005342-46-0
Compound CID: 24737642

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LCL-161, soluble in DMSO and warmed ethanol and insoluble in water, is a molecule designed to neutralize the function of IAPs, thereby promoting apoptosis, especially in cancer cells. It targets cIAP and XIAP.

Molecular Weight

500.2

Molecular Formula

C₂₆H₃₃FN₄O₃S

Targets

cIAP; XIAP

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (171.78 mM); Water: Insoluble; Warmed ethanol: 17 mg/mL (33.95 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

LCL-161 is investigated for its potential to degrade IAPs and induce apoptosis in cancer therapy research.

Storage

Store at -20ºC.