IDO inhibitor, Epacadostat, Purity ≥98%

Synonym: 1204669-58-8; INCB 024360; Epacadostat (INCB024360); (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine; INCB 24360; INCB-24360; 71596A9R13; N-(3-Bromo-4-fluoro-phenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine; N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide; N'-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboximidamide; IDO inhibitor

MDL: MFCD29075639
CAS Number: 1204669-58-8
Compound CID: 135564890

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Epacadostat, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting IDO. The molecular weight of the compound is 438.23, and its molecular formula is C₁₁H₁₃BrFN₇O₄S. It targets the IDO1.

Molecular Weight

438.23

Molecular Formula

C₁₁H₁₃BrFN₇O₄S

Targets

IDO1

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 74 mg/mL (168.86 mM); Water: insoluble; Ethanol (warmed): 45 mg/mL; In vivo: 5% DMSO + 40% PEG 300 + 5% TWEEN 80 + 50 % ddH₂O, 4.13 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Epacadostat plays a key role in reversing the immunosuppressive environment created by tumors and boosting the immune system’s ability to attack cancer cells.