IGF-1R inhibitor BMS-536924, Purity ≥98%

Synonym: 468740-43-4; IGF-1R inhibitor; BMS536924

CAS Number: 468740-43-4
Compound CID: 135440466

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BMS-536924, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets FAK, IGF-1R, Akt1, CDK2/CyclinE, EGF, HER2, Insulin receptor, LCK, MAPK1, MAPK2, and MEK.

Molecular Weight

480

Molecular Formula

C₂₅H₂₆ClN₅O₃

Targets

FAK: 150 nM; IGF-1R: 100 nM; Akt1: >5 μM; CDK2/CyclinE: >1 μM; EGF: 1.6 μM; HER2: 17.1 μM; Insulin receptor: 73 nM; LCK: 341 nM; MAPK1: >5 μM; MAPK2: 5 μM; MEK: 182 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (191.68 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

BMS-536924 is utilized to explore IGF-1 receptor inhibition and its therapeutic potential in cancer and metabolic disorder research.