IGF-1R inhibitor GSK1838705A, Purity ≥98%

Synonym: 1116235-97-2; IGF-1R inhibitor; GSK-1838705A

MDL: MFCD19443644
CAS Number: 1116235-97-2
Compound CID: 25182616

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK1838705A, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets IGF-1R, Insulin receptor, Akt1, Akt2, ALK, ALK5, ASK1, Aurora A, AuroraB, B-Raf(V600E), and CaMKK2.

Molecular Weight

532.57

Molecular Formula

C₂₇H₂₉FN₈O₃

Targets

IGF-1R: 2 nM; Insulin receptor: 1.6 nM; Akt1: >10 μM; Akt2: >10 μM; ALK: 0.5 nM; ALK5: >10 μM; ASK1: >25 μM; AuroraA: >10 μM; AuroraB: >10 μM; B-Raf (V600E): >2 μM; CaMKK2: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 103 mg/mL (193.4 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK1838705A is employed in studies aiming to inhibit IGF-1 receptor signaling, relevant for cancer treatment development.