IGF-1R inhibitor GSK1904529A, Purity ≥98%

Synonym: 1089283-49-7; IGF-1R inhibitor; GSK-1904529A

MDL: MFCD17010271
CAS Number: 1089283-49-7
Compound CID: 25124816

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK1904529A, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets B-Raf (V600E), IGF-1R, ActRIIB, Akt1, Akt2, ALK5, ASK1, Aurora A, AuroraB, CaMKK2, and CDK2/CyclinA.

Molecular Weight

852

Molecular Formula

C₄₄H₄₇F₂N₉O₅S

Targets

B-Raf (V600E): >2 μM; IGF-1R: 27 μM; ActRIIB: >10 μM; Akt1: >10 μM; Akt2: >10 μM; ALK5: >10 μM; ASK1: >25 μM; AuroraA: >8 μM; AuroraB: 4 nM; CaMKK2: >10 μM; CDK2/CyclinA: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 120 mg/mL (140.85 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK1904529A is used to investigate IGF-1 receptor blocking and its implications in targeting cancer cell growth.