IGF-1R inhibitor OSI-906, Purity ≥98%

Synonym: 867160-71-2; IGF-1R inhibitor; OSI906; Linsitinib

MDL: MFCD12912153
CAS Number: 867160-71-2
Compound CID: 11640390

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

OSI-906, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets Insulin receptor, IRR, Abl, Akt1, Akt2, ALK, Aurora A, AuroraB, BRK, BTK, and CDK1.

Molecular Weight

421.5

Molecular Formula

C₂₆H₂₃N₅O

Targets

Insulin receptor: 75 nM; IRR: 75 nM; Abl: >10 μM; Akt1: >10 μM; Akt2: >10 μM; ALK: >10 μM; AuroraA: >10 μM; AuroraB: >10 μM; BRK: >10 μM; BTK: >10 μM; CDK1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (189.8 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

OSI-906 is applied to study IGF-1 receptor blocking, which plays a vital role in cancer and metabolic disease research.