IKK/IκB inhibitor BAY 11-7085, Purity ≥98%

Synonym: bay 11-7085; 196309-76-9; (E)-3-(4-tert-Butylphenylsulfonyl)acrylonitrile; (E)-3-((4-(tert-Butyl)phenyl)sulfonyl)acrylonitrile; BAY 11-7083; bay11-7085; (E)-3-(4-tert-Butylphenyl)sulfonylprop-2-enenitrile; IKK/IκB inhibitor

MDL: MFCD01862602
CAS Number: 196309-76-9
Compound CID: 5353432

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BAY 11-7085, soluble in DMSO and ethanol and insoluble in water, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets IκBα phosphorylation.

Molecular Weight

249.33

Molecular Formula

C₁₃H₁₅NO₂S

Targets

IκBα phosphorylation: 10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 49 mg/mL (196.52 mM); Water: Insoluble; Ethanol: 49 mg/mL (196.52 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

BAY 11-7085 can be used to investigate its effects on inhibiting NF-κB activation by blocking IκBα phosphorylation.

Storage

Store at -20ºC.