IKK/IκB inhibitor Bay 11-7821, Purity ≥98%

Synonym: bay 11-7082; 19542-67-7; (E)-3-Tosylacrylonitrile; (E)-3-(p-Toluenesulfonyl)acrylonitrile; Bay 11-7821; BAY-11-7082; BAY11-7082; IKK/IκB inhibitor

MDL: MFCD00712162
CAS Number: 19542-67-7
Compound CID: 5353431

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Bay 11-7821, soluble in DMSO and ethanol and insoluble in water, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets E2-conjugating enzymes and IκBα phosphorylation (Tumor cells).

Molecular Weight

207.25

Molecular Formula

C₁₀H₉NO₂S

Targets

E2-conjugating enzymes; IκBα phosphorylation (Tumor cells): 10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 39 mg/mL (188.17 mM); Water: Insoluble; Ethanol: 10 mg/mL (48.25 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Bay 11-7821 can be employed to study its inhibition of NF-κB activation through suppression of IκB phosphorylation in inflammation and cancer models.