IKK/IκB inhibitor IKK epsilon-IN-1, Purity ≥98%

Synonym: 1292310-49-6; IKK epsilon-IN-1; TBK1/IKK|A-IN-2; 5-(2-((4-Morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile; IKK(epsilon)-IN-1 (IKKE-IN-1); IKKepsilon-IN-1; 5-[2-(4-Morpholin-4-ylanilino)pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrile; IKK/IκB inhibitor

MDL: MFCD28167836
CAS Number: 1292310-49-6
Compound CID: 51049969

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

IKK epsilon-IN-1, soluble in DMSO and insoluble in ethanol and water, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets IKKε and TBK1.

Molecular Weight

457.52

Molecular Formula

C₂₆H₂₇N₅O₃

Targets

IKKε: 3.9 nM (At 10 μM ATP); TBK1: 0.6 nM (At 5 μM ATP)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 57 mg/mL (124.58 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

IKK epsilon-IN-1 can be used to study its inhibitory effects on IKKε and its potential applications in inflammatory diseases.

Storage

Store at -20ºC.