IKK/IκB inhibitor MRT67307, Purity ≥98%

Synonym: MRT67307; 1190378-57-4; MRT-67307; MEY37JZ4XR; N-[3-[[5-Cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide; UNII-MEY37JZ4XR; IKK/IκB inhibitor

CAS Number: 1190378-57-4
Compound CID: 44464263

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MRT67307, soluble in warmed DMSO, water and ethanol, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets Autophagy, IKKε, TBK1, ULK1, and ULK2.

Molecular Weight

464.6

Molecular Formula

C₂₆H₃₆N₆O₂

Targets

Autophagy; IKKε: 160 nM (At 0.1 mM ATP); TBK1: 19 nM (At 0.1 mM ATP); ULK1: 45 nM; ULK2: 38 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 87 mg/mL; Water: 87 mg/mL; Ethanol: 87 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

MRT67307 can be used to investigate the inhibition of IκB kinase and its role in NF-κB pathway signaling.