Properties
Description
MRT67307, soluble in warmed DMSO, water and ethanol, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets Autophagy, IKKε, TBK1, ULK1, and ULK2.
Molecular Formula
C26H36N6O2
Targets
Autophagy; IKKε: 160 nM (At 0.1 mM ATP); TBK1: 19 nM (At 0.1 mM ATP); ULK1: 45 nM; ULK2: 38 nM
Solubility
Warmed DMSO: 87 mg/mL; Water: 87 mg/mL; Ethanol: 87 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
MRT67307 can be used to investigate the inhibition of IκB kinase and its role in NF-κB pathway signaling.
