IKK/IκB inhibitor PS-1145, Purity ≥98%

Synonym: PS-1145; 431898-65-6; PS 1145; IKK Inhibitor X; N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide; N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide; IKK/IκB inhibitor

MDL: MFCD18089825
CAS Number: 431898-65-6
Compound CID: 9949093

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PS-1145, soluble in DMSO and warmed ethanol and insoluble in water, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets IKK.

Molecular Weight

322.75

Molecular Formula

C₁₇H₁₁ClN₄O

Targets

IKK: 88 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 61 mg/mL (189 mM); Water: Insoluble; Warmed ethanol: 2 mg/mL (6.19 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PS-1145 can be used to explore its role as an IκB kinase inhibitor in regulating NF-κB signaling in various pathological conditions.

Storage

Store at -20ºC.