IKK/IκB inhibitor SC-514, Purity ≥98%

Synonym: SC-514; 354812-17-2; 4-Amino-[2,3'-bithiophene]-5-carboxamide; Sc 514; SC514; 3-amino-5-thiophen-3-ylthiophene-2-carboxamide; 3-Amino-5-(3-thienyl)thiophene-2-carboxamide; IKK/IκB inhibitor

CAS Number: 354812-17-2
Compound CID: 2807869

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SC-514, soluble in DMSO and insoluble in ethanol and water, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets AUR2, CDK2/CyclinA, cAbl, Chk1, EGFR, ERK2, FGFR1, GSK-3, IKK2, JNK1, and JNK2.

Molecular Weight

224.3

Molecular Formula

C₉H₈N₂OS₂

Targets

AUR2: 71 μM; CDK2/CyclinA: 61 μM; cAbl: >100 μM; Chk1: >100 μM; EGFR: >100 μM; ERK2: >100 μM; FGFR1: >100 μM; GSK-3: >100 μM; IKK2: 3-12 μM; JNK1: >200 μM; JNK2: >200 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 41 mg/mL (182.79 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SC-514 can be utilized to investigate its specific inhibitory effects on IKKβ in the NF-κB pathway in inflammation and cancer studies.

Storage

Store at -20ºC.