IKK/IκB inhibitor TPCA-1, Purity ≥98%

Synonym: TPCA-1; 507475-17-4; 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide; IKK-2 Inhibitor IV; TPCA1; 2-(Carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide; [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide; IKK/IκB inhibitor

MDL: MFCD09037541
CAS Number: 507475-17-4
Compound CID: 9903786

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TPCA-1, soluble in DMSO and insoluble in ethanol and water, modulates IKK-IκB signaling pathway, which plays a key role in inflammation and immune responses. It targets IKK2.

Molecular Weight

279.29

Molecular Formula

C₁₂H₁₀FN₃O₂S

Targets

IKK2: 17.9 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 49 mg/mL (175.44 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

TPCA-1 can be used to explore its specific inhibitory effects on IKK-β in the NF-κB signaling pathway in inflammatory diseases and cancer research.