Ingenol mebutate

Synonym: 75567-37-2; PEP005; PEP-005; PEP 005; Ingenol-3-angelate; I3A

Product Size

1 mg; 2 mg; 5 mg; 10 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Ingenol mebutate (PEP005) blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKC-α, PKC-β, PKC-δ, PKC-ε, and PKC-γ.

Molecular Weight

430.53

Molecular Formula

C₂₅H₃₄O₆

Targets

PKC-α: 0.3 nM; PKC-β: 0.105 nM; PKC-δ: 0.376 nM; PKC-ε: 0.171 nM; PKC-γ: 0.162 nM

Form

Lyophilized powder

Purity

>98%

Applications

Ingenol mebutate (PEP005) can be used for its effect on inducing cell death in abnormal keratinocytes, which are characteristic of AK lesions.