Properties
Description
Ingenol mebutate (PEP005) blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKC-α, PKC-β, PKC-δ, PKC-ε, and PKC-γ.
Molecular Formula
C25H34O6
Targets
PKC-α: 0.3 nM; PKC-β: 0.105 nM; PKC-δ: 0.376 nM; PKC-ε: 0.171 nM; PKC-γ: 0.162 nM
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ingenol mebutate (PEP005) can be used for its effect on inducing cell death in abnormal keratinocytes, which are characteristic of AK lesions.
Storage
Store at -20℃, and keep desiccated.
