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Inhibitors
The functions of cells are regulated by the kind of communication system known as a signal pathway, composed of a variety of proteins and other molecules, working together to perform basic functions such as growth, repair, or metabolism. Inhibitors are molecules that may interfere with the activity of a single or several components within an active signal pathway. They bind to the enzymes or proteins involved in these pathways and block, or change, signals released from them. Therefore, inhibitors provide invaluable tools for developing a flexible approach to understanding different types of disease.
Fig.1 The mechanisms of some inhibitors targeting the cancers. (Liu, et al., 2022)
CD BioGlyco provides a wide range of inhibitors that are precisely tailored to meet the research needs of our clients. In-depth investigation of various research fields is facilitated by our variety of inhibitor products, including oncology, cardiovascular diseases, endocrinology, epigenetics, immunology, metabolic processes, neuroscience, and inflammatory responses. Our inhibitors are designed to attack specific pathways and mechanisms involved in the development of these diseases, addressing their limitations as compared to conventional approaches. These inhibitors are classified according to signaling pathways.
Mechanical support needed for cellular functions such as division and movement is also provided by the cytoskeleton, which plays an essential role in keeping cells shaped and organization. Abnormalities in the cytoskeleton, crucial for cellular processes, often lead to disease. Cytoskeletal inhibitors are small compounds that interact with either actin or tubulin.
The inflammatory response is pivotal in immunity, triggering tissue damage and mobilizing the immune system. Immunology & inflammation inhibitors are used to dampen the immune system's reaction to damage, thereby lessening inflammation.
The ubiquitin system is crucial for maintaining protein balance and regulating proteins involved in various pathways like DNA repair, cell cycle, and signal transduction. When this system malfunctions, it can lead to diseases. Ubiquitin inhibitors block the process of ubiquitination, potentially preventing the attachment of ubiquitin to target proteins and interfering with various cellular processes regulated by ubiquitin-mediated signaling pathways.
PROTAC, a heterobi functional compound that consists of two active domains connected, is able to eliminate certain undesired proteins. PROTAC inhibitors function by inducing targeted intracellular proteolysis, unlike traditional inhibitors of enzymes.
With a focus on inhibitors, a cornerstone of modern targeted therapeutic research, CD BioGlyco also provides Glycosylation Inhibitor Development. If you are interested in our inhibitor products, please contact us.
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