Integrin inhibitor, Lifitegrast, Purity ≥98%

Synonym: 1025967-78-5; SAR-1118; SAR 1118; SAR1118; Lifitegrast; brand name: Xiidra.; (2S)-2-[[2-(1-Benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid

MDL: MFCD28502439
CAS Number: 1025967-78-5
Compound CID: 11965427

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

MSDS

Properties

Description

Lifitegrast, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting integrin.

Molecular Weight

615.478

Molecular Formula

C₂₉H₂₄Cl₂N₂O₇S

Form

Lyophilized powder

Purity

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 98 mg/mL (159.22 mM); Water: insoluble; Ethanol: 20 mg/mL

Applications

Lifitegrast is a cytoskeletal signaling inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of dry eye disease by blocking the interaction of integrin αLβ2 with its ligand, which reduces inflammation and improves symptoms.