Properties
Description
MK-0429 is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting integrin. It targets the α5β1, αvβ1, αvβ3, and αvβ5.
Molecular Formula
C23H29N5O4
Targets
α5β1: 12.2 nM (IC50, inhibition of fibronectin-binding); αvβ1: 1.6 nM (IC50, inhibition of fibronectin-binding ); αvβ3: 2.8 nM (IC50, inhibition of vitronectin-binding); αvβ5: 0.1 nM (IC50, inhibition of vitronectin-binding)
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
MK-0429 is a cytoskeletal signaling inhibitor that can be used for its effects on tumor growth, angiogenesis, and bone resorption.
Storage
Store at -20ºC, and keep desiccated.
