Isocitrate dehydrogenase (IDH) inhibitor, AGI-5198, Purity ≥98%

Synonym: 1355326-35-0; AGI5198; AGI 5198; IDHC35; N-Cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide; Isocitrate dehydrogenase (IDH) inhibitor

MDL: MFCD24848688
CAS Number: 1355326-35-0
Compound CID: 56645356

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AGI-5198, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting isocitrate dehydrogenase (IDH). The molecular weight of the compound is 462.56, and its molecular formula is C₂₇H₃₁FN₄O₂. It targets the R132C-IDH1 and R132H-IDH1.

Molecular Weight

462.56

Molecular Formula

C₂₇H₃₁FN₄O₂

Targets

R132C-IDH1

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 22 mg/mL (47.56 mM); Water: insoluble; Ethanol: 13 mg/mL (28.1 mM); In vivo: 0.5% methylcellulose + 0.2% Tween 80, 28 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

AGI-5198 can be studied extensively for its potential therapeutic applications in the treatment of certain types of brain tumors and acute myeloid leukemia (AML).