Isocitrate dehydrogenase (IDH) inhibitor, AGI-6780, Purity ≥98%

Synonym: 1432660-47-3; AGI6780; N-Cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide; AGI 6780; 1-[5-(Cyclopropylsulfamoyl)-2-thiophen-3-ylphenyl]-3-[3-(trifluoromethyl)phenyl]urea; Isocitrate dehydrogenase (IDH) inhibitor

MDL: MFCD26097285
CAS Number: 1432660-47-3
Compound CID: 71299339

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AGI-6780, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting isocitrate dehydrogenase (IDH). The molecular weight of the compound is 481.5, and its molecular formula is C₂₁H₁₈F₃N₃O₃S. It targets the IDH2 R140Q mutant.

Molecular Weight

481.5

Molecular Formula

C₂₁H₁₈F₃N₃O₃S

Targets

IDH2 R140Q mutant

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 87 mg/mL (180.68 mM); Water: insoluble; Ethanol: 87 mg/mL (180.68 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AGI-6780 can be studied extensively for its potential therapeutic applications in the treatment of cancers associated with IDH1 mutations.